MDR-1 DRUG SENSITIVITY TEST

 

Some breeds of dogs are more sensitive to certain drugs compared to other breeds. For example, Collies, Australian Shepherds and several other breeds are often more sensitive to the antiparasitic drug, ivermectin. This DNA cheek swab test is available from the Washington State University.
For more information and a list of problem drugs please check out the WSU WEBSITE.

Explanation Of Test Results:

NORMAL/NORMAL- These dogs do not carry the mutation, and will not pass on the mutation to their offspring. These dogs would not be expected to experience unexpected adverse drug reactions to normal doses of ivermectin, loperamide (Imodium®), and some anticancer drugs.

NORMAL/MUTANT- These dogs carry the mutation and may pass on the mutant gene to their offspring. These dogs may experience toxicity after normal doses of loperamide (Imodium®), and some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram).

MUTANT/MUTANT- These dogs carry the mutation and can not pass on a normal gene to their offspring. These dogs would be expected to experience toxicity after normal doses of loperamide (Imodium®), and some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram).

CLEAR BY PARENTAGE

Abbreviated as CBP, Clear By Parentage, simply indicates the dog itself was not tested and that the clearance is based on the sire and dam's DNA test results.